ACTIVITY OF LACTATE DEHYDROGENASE AND CONTENT OF CERULOPLASMIN IN HOOF DERMIS WITH CHRONIC LAMINITIS IN HORSES
DOI:
https://doi.org/10.37000/abbsl.2024.111.06Keywords:
horses, laminitis, pododermatitis, lactate dehydrogenase, ceruloplasmin.Abstract
Laminitis in horses is a complex, widespread and often relapsing disease characterized by a violation of the attachment of epidermocytes of the epidermal lamellae to the main membrane of the dermal plates, despite the variety of causes that cause the disease.
The mechanisms involved in the pathogenesis of laminitis are not fully understood and, most likely, are numerous and interrelated.
The aim of our research was to determine the activity of lactate dehydrogenase as an indicator enzyme of energy metabolism and glycolysis, as well as the concentration of ceruloplasmin as a reactant of the inflammatory inflammatory reaction in the base of the skin of the hooves of horses with acute pododermatitis and chronic laminitis.
It was established that in the conditions of the inflammatory process in the hoof dermis, a significant increase in the activity of lactate dehydrogenase is observed, apparently due to the development of lactic acidosis, energy deficiency, disruption of glycolytic processes and tissue metabolic adaptation. The study of the dermal concentration of ceruloplasmin in acute pododerma and chronic laminitis is an informative bioindicator for assessing the intensity of inflammation.
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