BIOCHEMICAL INDICATORS OF PIG BLOOD AS A RESULT OF SORBENT FEEDING
Keywords:
mycotoxins; pigs; blood biochemistry; sorbent; Harufix ; Klinotoksil; ProAktivo.Abstract
The deterioration of the mycotoxin situation in the world logically leads to an increase in the number of sorbent representatives on the market. When choosing a sorbent, attention is usually paid to its binding effect, but it is always necessary to take into account its possible impact on the animal body. Therefore, the purpose of the study was to determine changes in the biochemical parameters of pig blood as a result of the use of three sorbents. Therefore, 4 groups of animals were created in which blood was collected twice, followed by laboratory testing and detailed analysis of the results. Mycotoxin studies, in turn, did not reveal Zearalenone, DON in the blood of pigs throughout the study. «Harufix +» normalized the level of urea from 3.5 to 7.3 mmol/l (at a rate of 3.6-10.7), urea nitrogen from 6.7 to 14.05 mg% (at a rate of 7.6-19.1) and alkaline phosphatase from 240.5 to 132 U/l (at a rate of 60-190), while lowering glucose from 5.05 to 2.35 mmol/l (at a rate of 4.7-8.3). «ProAktivo» reduced alkaline phosphatase from 197 to 145 U/l (at a rate of 60-190), but caused deviations in albumin levels from 33.5 to 46.05 g/l (at a rate of 28-45) and AST from 44.5 to 23.5 U/l (at a rate of 32-84). «Clinotoxil» increased the ratio of albumin to globulin from 1.1 to 2.6 units. (norm 0.7-1.1), showing the least impact. The obtained results confirm the prospects of using these representatives in pig breeding, especially «Harufix+».
References
Begma, N. A. (2016). Biochemical blood parameters of young pigs when using Anisorb in compound feeds. Scientific and Technical Bulletin of the Research Center for Biosafety and Environmental Control of Agro-Industrial Complex Resources, 4(1), 27-31. https://dspace.dsau.dp.ua/handle/123456789/1359 (in Ukrainian)
Vasyanovych, O. M., Ruda, M. Ye., Sapeyko, V. P., et al. (2018). Study of the biosynthesis of fungi of the genus Fusarium moniliforme capable of producing mycotoxins—Fumonisins. Veterinary Biotechnology, 32(2), 60-67. https://surl.li/tydvwk (in Ukrainian)
Kobysh, A. I., Chechet, O. M., Shulyak, S. V., et al. (2021). The problem of the spread of toxicants in animal husbandry and the environment. Bulletin of Sumy National Agrarian University, 3(54), 17-25. https://doi.org/10.32845/bsnau.vet.2021.3.3 (in Ukrainian)
Levchenko, V. I., Sokolyuk, V. M., Bezukh, V. M., et al. (2002). Examination of animal blood and clinical interpretation of the obtained results. Methodical recommendations, 56. https://surl.li/thyikm (in Ukrainian)
Lohvynenko, N. M., Basarahin, V. A., Mamchenko, V. Yu. (2018). Prospects for the use of silicon sorbent Silard and feed concentrate Zhivyna in feeding young pigs and their impact on animal productivity. Scientific Horizons, 3(66), 50-55. https://surl.li/hgeyec (in Ukrainian)
Lohvynenko, S. L., Burlaka, V. A., Sychevska, N. M. (2016). Natural sorbents in the diets of animals with gastrointestinal type of digestion. Biological Research of PP Ruta, 354-356. https://surl.li/pvedfi (in Ukrainian)
Lyasota, V. P., Bukalova, N. V., Bohatko, N. M., et al. (2022). Hygienic justification of the use of the absorbent Polifan-K in pig rearing. Scientific Bulletin of Veterinary Medicine, 2, 6-19. https://surl.li/bujcqj (in Ukrainian)
Matsenko, E. V., Mohilovsky, V. M., Furda, I. V., et al. (2015). Application of the adsorbent Myamiko-Fit in chronic multiple mycotoxicosis in pigs. Scientific Bulletin of LNUVMBT, 17(2), 142-149. https://nvlvet.com.ua/index.php/journal/article/view/479 (in Ukrainian)
Reshetnichenko, A. O., Bezaltychyna, O. O. (2022). Use of the feed additive Kharufix+ in feeding weaned piglets. Actual aspects of the development of science and education. Collection of materials of the 2nd international scientific-practical conference of scientific-pedagogical workers and young scientists, 2, 251-255. https://surl.li/xwwnro (in Ukrainian)
Reshetnichenko, O. P., Sorokivska, O. S. (2022). Mycotoxicological evaluation of compound feeds for young pigs. Modern approaches to ensuring the safety and quality of livestock products, 126-128. http://lib.osau.edu.ua/jspui/handle/123456789/3987 (in Ukrainian)
Selishcheva, N. V., Bohach, M. V., Bohach, D. M. (2024). Mycological monitoring of grain feeds in southern Ukraine. Actual aspects of the development of veterinary medicine under conditions of European integration, 2, 148-151. https://surl.li/khagvk (in Ukrainian)
Solodka, L. O., Kryvda, M. I., Kostenok, S. V., et al. (2021). Microbial contamination of wheat grains grown in Zhytomyr Polissia. Bulletin of Sumy National Agrarian University. Series Veterinary Medicine, 4(55), 24-30. https://snaubulletin.com.ua/index.php/vm/article/view/570 (in Ukrainian)
Tytarova, O., Kryukova, L. (2020). Mycotoxin sorbents: the right choice. Animal Husbandry, Veterinary, 1, 52-54. https://surl.li/ototvg (in Ukrainian)
Chekan, O. M. (2022). Obstetric-gynecological dispensarization of cows in mycotoxicosis. Bulletin of Sumy National Agrarian University, 2(57), 53-60. https://doi.org/10.32845/bsnau.vet.2022.2.7 (in Ukrainian)
Chudak, R. A., Poberezhets, Yu. M., Ushakov, V. M., et al. (2021). Influence of feed additives and compound feeds on productivity and meat quality in pigs. Monograph, 203. http://socrates.vsau.org/repository/getfile.php/28824.pdf (in Ukrainian)
Shaiko, A. S. (2022). Study of the effectiveness of the probiotic Sporolex in pigs. Scientific Bulletin of Veterinary Medicine,, 1, 92-100. https://surl.li/fwjlzs (in Ukrainian)
Becker, C., Reiter, M., Pfaffl, M., Meyer, H., Bauer, J., & Meyer, H. (2021). Expression of immune relevant genes in pigs under the influence of low doses of deoxynivalenol (DON). Mycotoxin Res., 27, 287–293. https://doi.org/10.1007/s12550-011-0106-7
Council of Europe (1986). European Convention for the Protection of Vertebrate Animals used for Experimantal and Other Scientific Purposes. European Treaty Series, 123, 11. https://rm.coe.int/168007a67b
European Commission (2002). Directive 32/EC of the European Parliament and of the Council of 7 May 2002 on undesirable substances in animal feed. Official journal of the European Union, 140, 10–21. https://surl.li/bnbbho
Frobose, H., Fruge, E., Tokach, M., Hansen, E., DeRouchey, J., Dritz, S., & Nelssen, J. (2015). The effects of deoxynivalenol-contaminated corn dried distillers grains with solubles in nursery pig diets and potential for mitigation by commercially available feed additives. Journal of Animal Science, 93(3), 1074-1088. https://surl.li/axbaey
Kövesi, B., Kulcsár, S., Zándoki, E., Szabó-Fodor, J., Mézes, M., Balogh, K., Ancsin, Z., & Pelyhe, C. (2020). Short-term effects of deoxynivalenol, T-2 toxin, fumonisin B1 or ochratoxin on lipid peroxidation and glutathione redox system and its regulatory genes in common carp (Cyprinus carpio L.) liver. Fish physiology and biochemistry, 46(6), 1921–1932. https://doi.org/10.1007/s10695-020-00845-1
Kutsan, O., Orobchenko, O., Yaroshenko, M., & Gerilovich, I. (2020). Assessment of the degree of contamination of feed with microfungi and mycotoxins in the cattle industry of Ukraine in recent years. Bulletin of Agricultural Science, 98(2), 52-57. https://doi.org/10.31073/agrovisnyk202002-08
Lykhach, V., Lykhach, A., Faustov, R., Barkar, Y., & Lenkov, L. (2022). The effect of a new complex sorbent of mycotoxins in pigs diets on their growth performance, fattening and meat traits. Animal Science and Food Technology, 13(2), 26–34. https://surl.li/jgeova
Official Journal of the European Union L276/33. Directive 2010/63/eu of the european parliament and of the council of 22 September 2010 on the protection of animals used for scientific purposes. 86/609/EC. 20. 10. 2010.
R-Biopharm AG. (2023). RIDASCREEN® DON. Instructions for use of the kit for quantitative determination of deoxynivalenol. Darmstadt, Germany. https://food.r-biopharm.com/products/ridascreen-don/
R-Biopharm AG. (2023). RIDASCREEN® ZEA. Instructions for use of the kit for quantitative determination of zearalenone. Darmstadt, Germany. https://food.r-biopharm.com/products/ridascreen-zearalenon/
Sanin, O., Mikhalska, L., Dolgaleva, Yu., Zozulia, O., & Shvartau, V. (2019). The effect of fungicides and fertilizers on the content of mycotoxins in the grain of high-yielding winter wheat varieties. Plant Physiology and Genetics, 51(1), 67-76. https://doi.org/10.15407/frg2019.01.067
Starodub, M., Savchuk, M., Fedelesh-Gladinets, M., Taran, O., & Shulyak, L. (2019). Control of mycotoxin genotoxicity levels using an SOS-type optical fiber biosensor. Biological Systems: Theory and Innovations, 10(2), 38-43. https://surl.lu/oevabk
Tkaczyk, A., & Jedziniak, P. (2021). Development of a multi-mycotoxin LC-MS/MS method for the determination of biomarkers in pig urine. Mycotoxin Research, 37(2), 169-181. https://doi.org/10.1007/s12550-021-00428-w
Tkaczyk, A., & Jedziniak, P. (2021). Mycotoxin biomarkers in pigs-Current state of knowledge and analytics. Toxins, 13(8), 586. https://www.mdpi.com/2072-6651/13/8/586
Xu, Y., Pengle, L., Yilong, C., Bonan, X., Menglin, L., Miao, S., Wanyue, H., & Yanfei, L. (2020). Review of the Reproductive Toxicity of T-2 Toxin. Journal of agricultural and food chemistry, 68(3), 727–734. https://doi.org/10.1021/acs.jafc.9b07880
Yang, C., Song, G., & Lim, W. (2020). Effects of mycotoxin-contaminated feed on farm animals. Journal of Hazardous Materials Elsevier B.V., 389, 122087. https://doi.org/10.1016/j.jhazmat.2020.122087
Yorong, F., Yongcheng, J., Anshan, S., Jing, Z., Hongyu, T., Jinglin, S., Changhai, Z., Yao, Y., Hengtong, F., Yun, Z., Junxiong, W., & Yue, T. (2021). Polydatin Protects Bovine Mammary Epithelial Cells Against Zearalenone-Induced Apoptosis By Inhibiting Oxidative Responses and Endoplasmic Reticulum Stress. Toxins, 13(2), 121. https://www.mdpi.com/2072-6651/13/2/121
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