OPTIMIZATION OF THERAPEUTIC MEASURES FOR MALIGNANT NEOPLASIA OF THE MAMMARY GLANDS IN CATS
Keywords:
cats, neoplasms, mammary gland, mastectomy, chemotherapy, nonsteroidal anti-inflammatory drugs, hemostasis system.Abstract
The relevance of the problem of treating cats with malignant neoplasia of the mammary gland is related to the significant spread of neoplasms; the absolute advantage of their malignant types, which are characterized by high aggressiveness; insufficient treatment efficiency. Adjuvant chemotherapy with docetaxel and cyclophosphamide reduced the risk of disease progression by 1.5 times, its combination with meloxivet – by 2.2 times. Supplementation of the chemotherapeutic protocol with cyclooxygenase-2 inhibitor reduced the probability of recurrence in the thickness of the wound scar and adjacent tissues by 2.1 times, distant soft tissues by 3.1 times, lungs by 1.3 times. The inclusion of the non-steroidal anti-inflammatory drug meloxivet in the chemotherapy protocol for the treatment of cats with malignant mammary gland tumors ensured a faster dynamic reduction of the inflammatory reaction, which was confirmed by a reduction in the recovery time of such hemostasiological parameters as the duration of the activated partial thromboplastin time, prothrombic index, international normalized ratio, as well as fibrinogen content and platelet concentrations.
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