DIAGNOSIS AND TREATMENT OF DOGS WITH IDIOPATHIC EPILEPSY
DOI:
https://doi.org/10.37000/abbsl.2024.111.10Keywords:
dog, epileptic seizures, diagnostics, anticonvulsants, treatment effectiveness.Abstract
The paper analyses clinical cases of dogs with idiopathic epilepsy. The subjects were 12 dogs aged from one to five years with a history of frequent seizures with temporary loss of consciousness and an unspecified cause. Based on the results of an extended history, general clinical and special studies, a diagnosis of generalised idiopathic epilepsy was made. The prognosis for most of the research dogs is long-term - from favourable to cautious, depending on their clinical condition and the course of the disease. Treatment of the animals was aimed at controlling the frequency and nature of seizures. The treatment regimen for the experimental animals included the use of the anticonvulsant phenobarbital as a monotherapy and in combination with levetiracetam. The first signs of improvement in the physiological state of the animals were observed from the third day of treatment, and the final disappearance of clinical signs was observed within two weeks.
References
Гриценко О.В., Палюх Т.А. Лікування епілепсії у собак : матеріали Міжнародної наукової конференції Єдине здоров’я -2022, Київ, 22-24 вересня 2022 р., НУБіП України. С. 333-335
Bollinger-Schmitz, Kim and Kline, Karen (2000) "An Oveview of Canine Idiopathic Epilepsy for Small Animal Practitioner," Iowa State University Veterinarian: Vol. 62: Iss. 1, Article 14.
Rusbridge, C. (2014). Canine idiopathic epilepsy. In Practice, 36, 17-23. https://doi.org/10.1136/inp.g5126
Kearsley-Fleet, L., O'Neill, D. G., Volk, H. A., Church, D. B., & Brodbelt, D. C. (2013). Prevalence and risk factors for canine epilepsy of unknown origin in the UK. The Veterinary record, 172 (13), 338. https://doi.org/10.1136/vr.101133
Falco, M. J., Barker, J., & Wallace, M. E. (1974). The genetics of epilepsy in the British Alsatian. Journal of Small Animal Practice, 15 (11), 685-692.
Heske, L., Nødtvedt, A., Jäderlund, K. H., Berendt, M., & Egenvall, A. (2014). A cohort study of epilepsy among 665,000 insured dogs: incidence, mortality and survival after diagnosis. Veterinary journal (London, England : 1997), 202 (3), 471–476. https://doi.org/10.1016/j.tvjl.2014.09.023
Berendt, M., Gulløv, C. H., & Fredholm, M. (2009). Focal epilepsy in the Belgian shepherd: evidence for simple Mendelian inheritance. Journal of small animal practice, 50 (12), 655-661.
Jaggy, A., Faissler, D., Gaillard, C., Srenk, P., & Graber, H. (1998). Genetic aspects of idiopathic epilepsy in Labrador retrievers. Journal of Small Animal Practice, 39 (6), 275-280.
Smith, P. M., Talbot, C. E., & Jeffery, N. D. (2008). Findings on low-field cranial MR images in epileptic dogs that lack interictal neurological deficits. Veterinary journal (London, England : 1997), 176(3), 320–325. https://doi.org/10.1016/j.tvjl.2007.03.003.
Ekenstedt, K. J., & Oberbauer, A. M. (2013). Inherited epilepsy in dogs. Topics in companion animal medicine, 28 (2), 51–58. https://doi.org/10.1053/j.tcam.2013.07.001
Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian shepherd. Canine Medicine and Genetics, 7 (1), 1-11.
Seppälä, E. H., Jokinen, T. S., Fukata, M., Fukata, Y., Webster, M. T., Karlsson, E. K., & Lohi, H. (2011). LGI2 truncation causes a remitting focal epilepsy in dogs. PLoS genetics, 7 (7), e1002194.
Wielaender, F., Sarviaho, R., James, F., Hytönen, M. K., Cortez, M. A., Kluger, G., & Lohi, H. (2017). Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1. Proceedings of the National Academy of Sciences, 114 (10), 2669-2674.
Howbert, J. J., Patterson, E. E., Stead, S. M., Brinkmann, B., Vasoli, V., Crepeau, D., Vite, C. H., Sturges, B., Ruedebusch, V., Mavoori, J., Leyde, K., Sheffield, W. D., Litt, B., & Worrell, G. A. (2014). Forecasting seizures in dogs with naturally occurring epilepsy. PloS one, 9 (1), e81920. https://doi.org/10.1371/journal.pone.0081920
Moore S. A. (2013). A clinical and diagnostic approach to the patient with seizures. Topics in companion animal medicine, 28 (2), 46–50. https://doi.org/10.1053/j.tcam.2013.07.002
Muñana K. R. (2013). Management of refractory epilepsy. Topics in companion animal medicine, 28 (2), 67–71. https://doi.org/10.1053/j.tcam.2013.06.007
Chang, Y., Mellor, D. J., & Anderson, T. J. (2006). Idiopathic epilepsy in dogs: owners' perspectives on management with phenobarbitone and/or potassium bromide. The Journal of small animal practice, 47 (10), 574–581. https://doi.org/10.1111/j.1748-5827.2006.00203.
Patterson E. N. (2013). Epileptogenesis and companion animals. Topics in companion animal medicine, 28 (2), 42–45. https : // doi.org/10.1053/j.tcam.2013.06.010.
Podell M. (1998). Antiepileptic drug therapy. Clinical techniques in small animal practice, 13(3), 185–192. https://doi.org/10.1016/S1096-2867(98)80040-6
Podell, M., Volk, H. A., Berendt, M., Löscher, W., Muñana, K., Patterson, E. E., & Platt, S. R. (2016). 2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs. Journal of veterinary internal medicine, 30 (2), 477–490. https://doi.org/10.1111/jvim.13841
Berendt, M., Gulløv, C. H., & Fredholm, M. (2009). Focal epilepsy in the Belgian shepherd: evidence for simple Mendelian inheritance. Journal of small animal practice, 50 (12), 655-661.