INFLUENCE OF BIOLOGICALLY ACTIVE DRUGS ON THE ESTRUS CYCLE OF COWS
DOI:
https://doi.org/10.37000/abbsl.2024.111.04Keywords:
estrous cycle, cows, infertility, correction, estrus, cord blood serum, housing conditions.Abstract
Obtaining a stable profit in cattle breeding is possible only under conditions justified from the point of view of physiologically appropriate exploitation. At present, the technology of milk production in most farms of Ukraine is not provided with the necessary conditions for keeping cows, as there is not always full feeding, compliance with sanitary and hygienic conditions, and physiologically justified exploitation. Due to the biotic and abiotic load on the body of cows, there is a stress on the adaptive functioning of all systems, which, in some cases, goes beyond the limits of biological expediency . The article covers issues related to the correction of the estrous cycle of cows at the current level of animal husbandry in Ukraine. The corrective effect of biologically active compounds, namely cord blood serum and tissue drug "Actovegin" on the restoration of the sexual cycle of cows, when their physiological state is weakened and the barrier properties of the endometrium is disturbed, was revealed. The best biological effects were found with the combined use of cord blood serum and the tissue preparation "Aktovegin".It was established that when using cord blood serum in combination with the drug "Actovegin", the number of days from the correction of the reproductive function to the manifestation of the stage of excitement was 18.3% less compared to the indicator of the control group (4.31±0.38 and 18. 25±1.89, respectively).
References
Palii, А.P. Shkromada, O.I. Todorov, N.I.. Grebenik, N.P, Lazorenko, A.B. Bondarenko, I.V. Boyko, Y.A.Brit, O.V. Osipenko, T.L. Halay,O.Yu. Paliy A.P. (2020) Effect of linear traits in dairy cows on herd disposal Ukrainian Journal of Ecology, 10(3), x-xx, doi: 10.15421/2020.
Bondarenko I., Lazorenko A., Shkromada, O. (2021) Influence of cord blood serum and actovegin on the reproductive function of cows in the comparative aspect. EUREKA: Health Sciences, (3), 101-109. https://doi.org/10.21303/2504-5679.2021.001834
Бондаренко І.В. Сироватка кордової крові поєднано з актовегіном за корекції відтворної функції корів. Вісник сумського національного аграрного університету. Серія «Ветеринарна медицина». 2020. 4 (51), с. 39-45. Https://doi.org/10.32845/bsnau.vet.4.6.
Богданов Г.О. [та ін.]; за ред. В.М. Кандиби, І.І. Ібатулліна, В.І. Костенка. Теорія і практика нормованої годівлі великої рогатої худоби: монографія. Ж., 2012. 860 с.
Panossian A, Seo EJ, Efferth T. (2019). Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells. Phytomedicine. 2019 Jul;60:152881. doi: 10.1016/j.phymed.2019.152881. Epub 2019 Mar 10. PMID: 30987861.
Zhang, J., Lv, S., Liu, X., Song, B., and Shi, L. (2018). Umbilical cord mesenchymal stem cell treatment for crohn’s disease: a randomized controlled clinical trial. Gut Liver 12, 73–78. doi: 10.5009/gnl17035.
Riordan, N. H., Morales, I., Fernández, G., Allen, N., Fearnot, N. E., Leckrone, M. E., et al. (2018). Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis. J. Transl. Med. 16:57. doi: 10.1186/s12967-018-1433-7
Pittenger, M. F., Discher, D. E., Péault, B. M., Phinney, D. G., Hare, J. M., and Caplan, A. I. (2019). Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen. Med. 4, 1–15. doi: 10.1038/s41536-019-0083-6
Brock J, Golding D, Smith PM, Nokes L, Kwan A, Lee PYF. (2020) Update on the Role of Actovegin in Musculoskeletal Medicine: A Review of the Past 10 Years. Clin J Sport Med. Jan;30(1):83-90. doi: 10. 1097/JSM.0000000000000566. PMID: 31855916.
McLaughlin, C. A., West, T., Hollowell, R., Skergan, N. N., Baker, J., Donner, H., et al. (2019). Expanded access protocol of umbilical cord blood infusion for children with neurological conditions. Stem Cells Transl. Med. 8, S4–S5. doi: 10.1002/sctm.12583