MASTOPATHY IN DOGS AND CATS: FEATURES OF TREATMENT (REVIEW INFORMATION)
DOI:
https://doi.org/10.37000/abbsl.2024.110.08Keywords:
mastopathy, mammary gland, cats, dogs, treatment.Abstract
An analysis of modern literary sources concerning the specifics of treatment of mastopathy in dogs and cats was carried out. This analysis shows that mammary gland dysplasias in small animals are quite common. The methods of choice for their treatment are ovariohysterectomy and hormone therapy. Prevention of pathology is carried out by ovariectomy before the first oestrus. This surgical intervention significantly reduces the risk of pathology. Ovarian estrogens and progesterone affect the development of mammary glands. They regulate proliferation and differentiation of epithelial cells, promote proliferation processes in the mammary gland. Surgical resection is widely used for the treatment of neoplasms. It is important to determine the type of tumors and analyze prognostic information, as they differ significantly in terms of morphological features and biological behavior. At this time, histological diagnosis provides the basis for appropriate treatment and follow-up. Early detection and optimal surgical intervention play an important role. Benign tumors also require surgical removal. Radical mastectomy for mastopathy is necessary in the late stages of the disease. Conservative treatment is based on the progesterone antagonist aglepristone, since progesterone and its synthetic analogues play a decisive role in the occurrence of this pathology. Aglepristone is a competitive progesterone antagonist indicated for the treatment of various progesterone-dependent physiological or pathological conditions. The analysis of literary sources showed that today, during the treatment of mastopathy, very little attention is paid to homeopathic remedies, which are successfully used in humane medicine for this pathology. Further research is needed to study the effectiveness of homeopathic medicines in the complex treatment of mastopathy in dogs and cats.
References
Abeer, A. M., Zakia, A. M., Muna, E. A., & Afaf, E. A. (2016). Incidence of multiple mammary tumours and fibroadenoma in the pathological study of udder affections in camel (Camelus dromedarius). Journal of Cancer and Tumor International, 4(1), 1–7. doi:10.9734/JCTI/2016/24542
Akter, A., & Alam M. (2022). Regional mastectomy for mammary gland tumor in a bitch: A case report. Veterinary Research Notes, 2(12), 86–90. doi:10.5455/vrn.2022.b19.
Amorim, F. V., Souza, H. J. M., Ferreira, A. M. R., & Fonseca A. B. M. (2006). Clinical, cytological and histopathological evaluation of mammary masses in cats from Rio de Janeiro, Brazil⋆. Journal of Feline Medicine and Surgery, 8(6), 379–388. doi: 10.1016/j.jfms.2006.04.004
Anderson, D. (2014). Mammary tumours in the dog and cat (part 2): surgical management. Companion Animal, 19(12). doi: 10.12968/coan.2014.19.12.648
Assis, M. M. Q., Sala, P. L., Ceranto, A. C. S., Borges, T. B., Leitzke, A. V. S., Belettini, S. T., Boscarato, A. G., & Quessada, A. M. (2023). Alterações macroscópicas nas glândulas mamárias de gatas hígidas após administração de progestágeno. Semina: Ciências Agrárias, 44(3), 1059–1066. doi: 10.5433/1679-0359.2023v44n3p1059
Bilyi, D. D., & Khomutenko, V. L. (2022). Canine mastopathy (Overview). Theoretical and Applied Veterinary Medicine, 10(4), 3–11. doi: 10.32819/2022.10016
Bonatto, G. L., Silva, V. G., Favero, L. J., Kano, N. N., de Sousa, R. S., & Albernaz, V. G. P. (2021). Mammary Fibroepithelial Hyperplasia in a Male Cat. Acta Scientiae Veterinariae, 49. doi: 10.22456/1679-9216.111672
Burstyn U. (2010). Management of mastitis and abscessation of mammary glands secondary to fibroadenomatous hyperplasia in a primiparturient cat. Journal of the American Veterinary Medical Association, 236(3), 326–329. doi: 10.2460/javma.236.3.326
Carvalho Ferreira, M. I., & Pinto, L. F. (2008). Homeopathic treatment of vaginal leiomyoma in a dog: case report. Іnternational Journal of High Dilution Research, 7(24), 152–158. doi:10.51910/ijhdr.v7i24.304
Colodel, M. M., Ferreira, I., Figueiroa, F. C., & Rocha, N. S. (2012). Efficacy of fine needle aspiration in the diagnosis of spontaneous mammary tumors. Veterinaria e Zootecnia, 19(4), 557–563.
De Melo, E. H. M., Câmara, D. R., Notomi, M. K., Jabour, F. F., Garrido, R. A., Nogueira, A. C. J., Júnior, J. C. S., & De Souza, F. W. (2021). Effectiveness of ovariohysterectomy on feline mammary fibroepithelial hyperplasia treatment. Journal of Feline Medicine and Surgery, 23(4), 351–356. doi:10.1177/1098612X20950551
De Sant’Ana, F. J., Carvalho, F. C., de O. Gamba, C., Cassali, G. D., Riet-Correa, F., & Schild, A. L. (2014). Mammary diffuse fibroadenomatoid hyperplasia in water buffalo (Bubalus bubalis): three cases. Journal of Veterinary Diagnostic Investigation, 26(3), 453–456. doi: 10.1177/1040638714526595
Diep, H., Daniel, A. R., Mauro, L. J., & Lange, V. A. (2015). Progesterone action in breast, uterine, and ovarian cancers. Journal of Molecular Endocrinology, 54(2), 1–17. doi: 10.1530/JME-14-0252
Ferreira, E., Gobbi, H., Saraiva, B. S., & Cassali, G. D. (2012). Histological and immunohistochemical identification of atypical ductal mammary hyperplasia as a preneoplastic marker in dogs. Veterinary Pathology, 49(2), 322–329. doi:10.1177/0300985810396105
Fesseha, H. (2020). Mammary Mastectomy Due to Mammary Gland Tumors in Intact Female Dog. Biomedical Journal of Scientific & Technical Research, 28(1), 21224–21228. doi: 10.26717/BJSTR.2020.28.004589
Filgueira, K. D., Reis, P. F. C., Macêdo, L. B. Oliveira, I. V. P., Pimentel, M. M. L., & Reche Júnior, A. (2015). Clinical and therapeutic characterization of nonneoplastic mammary lesions in feline species females. CAB Direct, 9(1), 98–107.
Gaertner, K., Müllner, M., Friehs, H., Schuster, E., Marosi, C., Muchitsch, I., Fras, M., & Kaye, A. D. (2014). Additive homeopathy in cancer patients: Retrospective survival data from a homeopathic outpatient unit at the Medical University of Vienna. Complementary Therapies in Medicine, 22(2), 320–332. doi:10.1016/j.ctim.2013.12.014
Giménez, F., Hecht, S., & Legendre, A. (2010). Early Detection, Aggressive Therapy: Optimizing the Management of Feline Mammary Masses. Journal of Feline Medicine and Surgery, 12(3), 214–224. doi: 10.1016/j.jfms.2010.01.004
Gogny, A., & Fiéni, F. (2016). Aglepristone: A review on its clinical use in animals. Theriogenology, 85 (4), 555–566.
Görlinger, S., Kooistra, H. S., Broek, A., & Okkens, A.C. (2008). Treatment of Fibroadenomatous Hyperplasia in Cats with Aglépristone. Journal of Veterinary Internal Medicine, 16(6), 640–749. doi:10.1111/j.1939-1676.2002.tb02412.x
Golchin, D., Sasani, F., Pedram, M. S., & Khaki, Z. (2023). Clinicopathological Diversity and Epidemiological Aspects of Canine and Feline Mammary Gland Tumors in Tehran: A Survey (2020-2022). Iranian Journal of Veterinary Medicine, 17(3), 231–242. doi: 10.32598/ijvm.17.3.1005291
Gupta, P., Raghunath, M., Gupta, A. K., Sharma, A., & Kour, K. (2014). Clinical study for diagnosis and treatment of canine mammary neoplasms (CMNs) using different modalities. Indian Journal of Animal Research, 48(1), 45–49. doi:10.5958/j.0976-0555.48.1.009
Hershey, B., Shanan, A., Pierce, J., & Shearer, T. (2023). Integrative Therapies for Palliative Care of the Veterinary Cancer Patient. Hospice and Palliative Care for Companion Animals: Principles and Practice, Second Edition, doi: 10.1002/9781119808817.ch11
Horta, R., Lavalle, G., Cunha, R., Moura, L., Araújo, R., & Cassali, G. (2014). Influence of Surgical Technique on Overall Survival, Disease Free Interval and New Lesion Development Interval in Dogs with Mammary Tumors. Advances in Breast Cancer Research, 3(2), 38–46. doi: 10.4236/abcr.2014.32006.
Jaguezeski, A. M., Glombowsky, P., Da Rosa, G, & Da Silva, A. S. (2021). Daily intake of a homeopathic agent by dogs modulates white cell defenses and reduces bacterial counts in feces. Microbial Pathogenesi, 156, 104936. doi:10.1016/j.micpath.2021.104936
Jurka, P., & Max, A. (2009). Treatment of fibroadenomatosis in 14 cats with aglepristone – changes in blood parameters and follow-up. Veterinary Record Case Reports, 165(22), 657–660. doi: 10.1136/vr.165.22.657
Kaszak, I., Witkowska-Piłaszewicz, O., Domrazek, K., & Jurka, P. (2022). The novel diagnostic techniques and biomarkers of canine mammary tumors. Veterinary Sciences, 9(10), doi:526. 10.3390/vetsci9100526
Keskin, A., Yilmazbas, G., & Gumen, A. (2009). Pathological abnormalities after long-term administration of medroxyprogesterone acetate in a queen. Journal of Feline Medicine and Surgery, 11(6), 518–521. doi: 10.1016/j.jfms.2008.10.006
Kovalenko, M., & Bilyi, D. (2021). Prognostic value of vascular invasion in breast tumours in she-dogs (pilot study). Scientific Horizons, 24(2), 54–61. doi:10.48077/scihor.24(2).2021.54-61
Kristiansen, V. M., Nødtvedt, A., Breen, A. M., Langeland, M., Teige, J., Goldschmidt, M., & Sørenmo, K. (2013). Effect of ovariohysterectomy at the time of tumor removal in dogs with benign mammary tumors and hyperplastic lesions: a randomized controlled clinical trial. Journal of Veterinary Internal Medicine, 27(4), 935–942. doi: 10.1111/jvim.12110
Kula, H., & Uçmak, Z. G. (2022). Feline fibroepithelial hyperplasia and current treatment protocols. Journal of Istanbul Veterınary Scıences, 6(1), 18–25. doi: 10.30704/http-www-jivs-net.1031677
Lees, P., Pelligand, L., Whiting, M., Chambers, D., Toutain, P. L., & Whitehead, M. L. (2017). Comparison of veterinary drugs and veterinary homeopathy: part 2. Veterinary Record, 181(8), 198–207. doi: 10.1136/vr.104279
Lieshova, М. О., Shuleshko, О. О., & Balchugov, V. О. (2018). Poshyrennia і struktura novoutvoren tvaryn u misti Dnipro. Naukovo-tekhnichnyi biuleten NDTs biobezpeky ta ekolohichnoho kontroliu resursiv APK, 6 (2), 30–37. [In Ukrainian]
Loretti, A. P., Silva Ilha, M. R., Ordás, J., & Mulas, J. M. (2005). Clinical, pathological and immunohistochemical study of feline mammary fibroepithelial hyperplasia following a single injection of depot medroxyprogesterone acetate. Journal of Feline Medicine and Surgery, 7(1), 43–52. doi:10.1016/j.jfms.2004.05.002
Lopes, D. F., Benedictis Andreta, A. C., & Traldi, R. F. (2022). Integrative Clinical Treatment of Grade II Soft Tissue Sarcoma with Homeopathic Mistletoe and Associations: Case Report. Journal of Pharmacy and Pharmacology, 10, 55–61. doi: 10.17265/2328-2150/2022.02.004
Marino, G., Pugliese, M., Pecchia, F., Garufi, G., Lupo, V., Di Giorgio, S., & Sfacteria, A. (2021). Conservative treatments for feline fibroadenomatous changes of the mammary gland. Open Veterinary Journal, 11(4): 680–685. doi:10.5455/OVJ.2021.v11.i4.19
Marinelli, L., Gabai, G., Wolfswinkel, J., & Mol, J. A. (2004). Mammary steroid metabolizing enzymes in relation to hyperplasia and tumorigenesis in the dog. The Journal of Steroid Biochemistry and Molecular Biology, 92(3), 167–173. doi:10.1016/j.jsbmb.2004.08.001
Marchiori, M. S., Da Silva, A. S., Glombowsky, P., Campigotto, G., Favaretto, J. A., & Jaguezeski, A.M. (2019). Homeoppatic product in dog diets modulate blood cell responses. Archives of Veterinary Science, 24(4), 92–101. doi:10.5380/avs.v24i4.69072
Maslikov, S. M., Samoiliuk, V. V., Riznyk, V. A., & Kozii, M. S. Efektyvnist homeopatychnykh preparativ v kompleksnomu likuvanni mastopatii u kishok (2011). Vynakhidnytstvo ta ratsionalizatorstvo u medytsyni, biolohii ta ekolohii: Materialy I Mizhnar. nauk.-prakt. konf. studentiv ta molodykh vchenykh, 19-20 veresnia 2018 r.) / Dniprovskyi DAEU. – Dnipro, 38–45. [In Ukrainian]
Mathie, R. T., Baitson, E. S., Hansen, L., Elliott, M. F., & Hoare, J. (2010). Homeopathic prescribing for chronic conditions in feline and canine veterinary practice. Homeopathy, 99(04), 243–248. doi: 10.1016/j.homp.2010.05.010
Mayayo, S. L., Bo, S., & Pisu, M. C. (2018). Mammary fibroadenomatous hyperplasia in a male cat. Journal of Feline Medicine and Surgery, 4(1). doi:10.1177/2055116918760155
Meisl, D., Hubler, M., & Arnold, S. (2003). [Treatment of fibroepithelial hyperplasia (FEH) of the mammary gland in the cat with the progesterone antagonist Aglépristone (Alizine)]. Schweizer Archiv fur Tierheilkunde, 145(3):130–136. doi: 10.1024/0036-7281.145.3.130
Miklashevska, O. A. (2022). Endometriozasotsiiovani dysplazii molochnykh zaloz: osoblyvosti diahnostyky ta likuvannia. Visnyk medychnykh i biolohichnykh doslidzhen, 2(12), 75–79. doi:10.11603/bmbr.2706-6290.2022.2.13048. [In Ukrainian]
Morrison, W. B. (2011). Inflammation and Cancer: A Comparative View. Journal of Veterinary Internal Medicine, 26(1), 18–31. doi:10.1111/j.1939-1676.2011.00836.x
Murphy, C. B., Hoelzler, M. G., Newgent, A. R., & Botchway, A. (2023). Incidentally diagnosed mammary gland tumors are less likely to be malignant than nonincidental mammary gland tumors. Journal of the American Veterinary Medical Association, 261: 10. doi: 10.2460/javma.23.03.0133
Overley, B., Shofer, F. S., Goldschmidt, M. H., Sherer, D., & Sorenmo, K.U. (2005). Association between Ovarihysterectomy and Feline Mammary Carcinoma. Journal of Veterinary Internal Medicine, 19(4), 489–629. doi: 10.1111/j.1939-1676.2005.tb02727.x
Papparella, S., Crescio, M. I., Baldassarre, V. Brunetti, B., Burrai, G. P., Cocumelli, C., Grieco, V. Iussich, S., Maniscalco, L., & Mariotti, F. (2022). Reproducibility and Feasibility of Classification and National Guidelines for Histological Diagnosis of Canine Mammary Gland Tumours: A Multi-Institutional Ring Study. Veterinary Sciences, 9(7), 357. doi: 10.3390/vetsci9070357
Pickard Price, P., Stell, A., O'Neill, D., Church, D., & Brodbelt, D. (2023). Epidemiology and risk factors for mammary tumours in female cats. Journal of Small Animal Practice, 64(5), 313–320. doi: 10.1111/jsap.13598
Samoiliuk, V. V., Bilyi, D. D., & Shevchenko, Y. Y. (2014). Osoblyvosti likuvannia novoutvoren molochnykh zaloz iz oznakamy vyrazhenoho zapalennia u sobak. Naukovo-tekhnichnyi biuleten NDTs biobezpeky ta ekolohichnoho kontroliu resursiv APK, 2(3). 8–13. [In Ukrainian]
Sampayo, R., Recouvreux, S., & Simian, M. (2013). Chapter Six - The Hyperplastic Phenotype in PR-A and PR-B Transgenic Mice: Lessons on the Role of Estrogen and Progesterone Receptors in the Mouse Mammary Gland and Breast Cancer. Vitamins & Hormones, 93, 185–201. doi: 10.1016/B978-0-12-416673-8.00012-5
Sewoyo, P. S., Mirah Adi, A. A., Oka Winaya, I. B., & Wirata, I. W. (2023). Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study. Jurnal Medik Veteriner, 6(2), 271287. doi:10.20473/jmv.vol6.iss2.2023.271287
Simon, D., Schoenrock, D., Nolte, I., Baumgärtner, W., Barron, R., & Mischke, R. (2009). Cytologic examination of fine-needle aspirates from mammary gland tumors in the dog: diagnostic accuracy with comparison to histopathology and association with postoperative outcome. Veterinary Clinical Pathology, 38(4), 521–528. doi: 10.1111/j.1939-165X.2009.00150.x
Sobchuk, M. V., & Sliusarenko, D. V. (2021). Distribution and structure of cat's mammary tumors (review article). Veterinary science, technologies of animal husbandry and nature management, 7, 141–145. doi: 10.31890/vttp.2021.07.21
Solano-Gallego, L., & Masserdotti, C. (2016). Reproductive System. Canine and Feline Cytology. 313–352. doi: 10.1016/B978-1-4557-4083-3.00012-7
Sontas, B. H, Öztürk, G. Y., Toydemir, T. F. S., Arun, S. S., & Ekici, H. (2011). Fine-Needle Aspiration Biopsy of Canine Mammary Gland Tumours: A Comparison Between Cytology and Histopathology. Reproduction in Domestic Animals, 47(1), 125–130. doi: 10.1111/j.1439-0531.2011.01810.x
Schrank, M., Bonsembiante, F., Fiore, E., Bellini, L., Zamboni, C., Zappulli, V., & Mollo, A. (2017). Diagnostic approach to fibrocystic mastopathy in a goat: termographic, ultrasonographic, and histological findings. Large Animal Review, 23(1), 33–37.
Tabrizi, S. O., Meedya, S., Ghassab-Abdollahia, N., Ghorbani, Z., Jahangiry, L., & Mirghafourvand, M. (2021). The effect of the herbal medicine on severity of cyclic mastalgia: a systematic review and meta-analysis. Journal of Complementary and Integrative Medicine, 19(4), 855–868. doi: 10.1515/jcim-2020-0531
Timmermans-Sprang, E., Gracanin, A., & Mol, J. A. (2017). Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification. Frontiers in Veterinary Science, 4:53. doi: 10.3389/fvets.2017.00053
Torrigiani, F., Moccia, V., Brunetti, B., & Millanta, F. (2022). Mammary Fibroadenoma in Cats: A Matter of Classification. Veterinary Sciences, 9(6), 253. doi: 10.3390/vetsci9060253
Turashvili, G., & Li, X. (2023). Inflammatory Lesions of the Breast. Archives of Pathology & Laboratory Medicine, 147(10), 1133–1147. doi:10.5858/arpa.2022-0477-RA
Vanderperren, K., Saunders, J. H., Van der Vekens, E., Wydooghe, E., Rooster, H., Duchateau, L., & Stock, E. (2018). B-mode and contrast-enhanced ultrasonography of the mammary gland during the estrous cycle of dogs. Animal Reproduction Science, 199, 15–23. doi: 10.1016/j.anireprosci.2018.08.036
Vichi, G., Fratto, A., & Manuali, E. (2021). Epidemiological Data of Feline Neoplastic Diseases and Suggestions for Improvement of Data Collection. Journal of Oncology Research and Treatments, S2:003
Vitásek, R., & Dendisová, H. (2006). Treatment of Feline Mammary Fibroepithelial Hyperplasia Following a Single Injection of Proligestone. Journal of the University of Veterinary Sciences Brno, 75(2), 295–297. doi:10.2754/avb200675020295