ANATOMO-TOPOGRAPHIC FEATURES OF LYMPHATIC NODES OF LABORATORY RATS THAT RECEIVED A HIGH-FAT DIET
DOI:
https://doi.org/10.37000/abbsl.2022.105.07Keywords:
organs of hemopoiesis and lymphopoiesis, absolute and relative weight, length, width, high-fat dietAbstract
Lymph nodes are peripheral organs of hemopoiesis and lymphopoiesis that provide lymph filtration and the function of antigen-dependent proliferation and differentiation of immunocompetent cells. Features of the topography and macrostructure of somatic and visceral lymph nodes of sexually mature white laboratory rats, which received a high-fat diet for 30 days, were considered. It was determined that the lymph nodes of this type of mammal belong to the group of mononodose single nodes. Macroscopically, each examined organ is characterized by a polar structure with the definition of two main zones: a convex surface (place of entry of afferent lymphatic vessels) and a portal cavity (with blood and efferent lymphatic vessels). The high-fat diet of rats does not affect the topography and macroscopic indicators of somatic and visceral lymph nodes. The mass of lymph nodes in rats varies significantly, depending on their topographical location: among somatic, it is maximal in the Inn. facials and Inn. cervicales superficiales, and among visceral - in the Inn. ileocaecalis and In. jugularis internus.
References
Andreeva, I. V., Vinogradov, A. A., & Abrosimova, T. N. (2008) Osobennosti ultrazvukovoy anatomii organov bryushnoy polosti kryis [Features of ultrasound anatomy of the abdominal organs of rats]. Ukrainskyi medychnyi almanakh, 6 (1), 11–13 (in Russian).
Bilan, M. V., Lieshchova, M. A., Tishkina, N. M., & Brygadyrenko, V. V. (2019). Combined effect of glyphosate, saccharin and sodium benzoate on the gut microbiota of rats. Regulatory Mechanisms in Biosystems, 10(2), 228–232. http://doi.org/10.15421/021934
Brygadyrenko, V. V., Lieshchova, M. A., Bilan, M. V., Tishkina, N. M., & Horchanok, A. V. (2019). Effect of alcohol tincture of Aralia elata on the organism of rats and their gut microbiota against the background of excessive fat diet. Regulatory Mechanisms in Biosystems, 10(4), 497–506. http://doi.org/10.15421/021973
Dijkstra, C. D., Kamperdijk, E. W .A., & Veerman, A. J. P. (1990). Normal Anatomy, Histology, Immunohistology, and Ultrastructure, Lymph Node, Rat. In: Jones, T. C., Ward, J. M., Mohr, U., Hunt, R. D. (eds) Hemopoietic System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84110-1_20
Harapko, T. V. (2020). Histological changes of structural components in lymph nodes of rats and changes in biochemical blood indices in experimental obesity. Світ медицини та біології, 1(71), 169–173. DOI 10.26724/2079-8334-2019-4-70-169-173
Holovatskyi, A. S., & Valko, O. O. (2016). Morfofunktsionalni zminy v limfatychnykh vuzlakh pry diyi na orhanizm khimichnykh i fizychnykh chynnykiv. Naukovyi visnyk Uzhhorodskoho universytetu. Seriya “Medytsyna”, 1(53), 131–136 (in Ukrainian).
Jia, L., Xie, Z., Zheng, J., Liu, L., He, Y., Liu, F., & He, Y. (2012). Morphological studies of lymphatic labyrinths in the rat mesenteric lymph node. Anatomical record (Hoboken, N.J.: 2007), 295(8), 1291–1301. https://doi.org/10.1002/ar.22509
Lieshchova, M. A., & Brygadyrenko, V. V. (2021). Influence of Lavandula angustifolia, Melissa officinalis and Vitex angus-castus on the organism of rats fed with excessive fat-containing diet. Regulatory Mechanisms in Biosystems, 12(1), 169–180. http://doi.org/10.15421/022125
Lieshchova, M. A., Bilan, M. V., Bohomaz, A. A., Tishkina, N. M., & Brygadyrenko, V. V. (2020). Effect of succinic acid on the organism of mice and their intestinal microbiota against the background of excessive fat consumption. Regulatory Mechanisms in Biosystems, 11(2), 153–161. http://doi.org/10.15421/022023
Lieshchova, M. A., Bohomaz, A. A., & Brygadyrenko, V. V. (2021). Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet. Regulatory Mechanisms in Biosystems, 12(3), 554-563. https://doi.org/10.15421/022176
Lieshchova, M., & Brygadyrenko, V. (2022). Effects of Origanum vulgare and Scutellaria baicalensis on the Physiological Activity and Biochemical Parameters of the Blood in Rats on a HighFat Diet. Scientia Pharmaceutica, 90(3), 49.
Ohtani, O., & Ohtani, Y. (2008). Structure and function of rat lymph nodes. Archives of histology and cytology, 71(2), 69–76. https://doi.org/10.1679/aohc.71.69
Ohtani, O., Ohtani, Y., Carati, C. J., & Gannon, B. J. (2003). Fluid and cellular pathways of rat lymph nodes in relation to lymphatic labyrinths and Aquaporin-1 expression. Archives of histology and cytology, 66(3), 261–272. https://doi.org/10.1679/aohc.66.261
Okada, S., Albrecht, R. M., Aharinejad, S., & Schraufnagel, D. E. (2002). Structural aspects of the lymphocyte traffic in rat submandibular lymph node. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 8(2), 116–133. https://doi.org/10.1017/s1431927601020049
Shaikh, S. R., Haas, K. M., Beck, M. A., & Teague, H. (2015). The effects of diet-induced obesity on B cell function. Clinical & Experimental Immunology, 179(1), 90–95.
Suami, H., & Scaglioni, M. F. (2017). Lymphatic Territories (Lymphosomes) in the Rat: An Anatomical Study for Future Lymphatic Research. Plastic and reconstructive surgery, 140(5), 945–951. https://doi.org/10.1097/PRS.0000000000003776
Suami, H., Chang, D. W., Matsumoto, K., & Kimata, Y. (2011). Demonstrating the lymphatic system in rats with microinjection. Anatomical record (Hoboken, N.J.: 2007), 294(9), 1566–1573. https://doi.org/10.1002/ar.21446
Valko, O. O., Holovatskyi, A. S., Nebesna, Z. M., Volkov, K. S., & Kramar, S. B. (2017). Strukturni zminy limfatychnykh vuzliv bilykh shchuriv pry dvotyzhnevomu ta chotyrytyzhnevomu opioidnomu vplyvi. Naukovyi visnyk Uzhhorodskoho universytetu. Seriya “Medytsyna”, 2(56), 7–10 (in Ukrainian).
Yakubtsova, I. V., Khilko, T. D., Savytska, I. M., Konopelniuk, V. V., Preobrazhenska, T. D., & Makai, Sh. (2016). Vplyv Trigonella foenum graecum L. na stan imunokompetentnykh orhaniv za umov diyetindukovanoho ozhyrinnia u shchuriv. Scientific Journal “ScienceRise: Biological Science”, 3(3), 53–60 (in Ukrainian).
