MORPHOLOGICAL EFFECT OF ANTIBACTERIAL SUTURE MATERIALS VICRYL PLUS AND SILVER PGA ON WOUND HEALING
Keywords:
Vicryl Plus, Silver PGA, wound healing, tissue response.Abstract
This study presents the results of an experimental investigation of tissue response to two modern absorbable suture materials - Vicryl Plus and Silver PGA - in a soft tissue injury model of the femoral region in pigs. Both materials exhibit antimicrobial properties through different mechanisms: a triclosan coating in Vicryl Plus and silver content in Silver PGA. The study was conducted on two groups of animals, with tissue samples collected on days 7 and 14 for histological, morphometric, and microbiological analyses. Morphological observations demonstrated that by day 7, granulation tissue formed around both suture materials; however, the cellular composition and intensity of inflammation differed. Vicryl Plus induced moderate macrophage-lymphocyte infiltration, whereas Silver PGA showed a less pronounced inflammatory response and a more uniform granulation tissue structure, correlating with the effective antimicrobial action of silver. By day 14, inflammation was reduced, and the reactive zone progressed to the fibroplasia stage. The fibrous capsule surrounding Silver PGA was thinner than that around Vicryl Plus, indirectly indicating higher biocompatibility of the material. In both groups, there was progressive organization of collagen fibers, restoration of epidermal stratification, and normalization of hypodermal structure. The data confirm that both suture materials exhibit good biocompatibility and positively influence the early phases of wound healing. At the same time, Silver PGA induces a slightly weaker inflammatory response, which may be clinically relevant in situations with an increased risk of infectious complications.
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