CHANGES IN THE BIOCHEMICAL AND MORPHOLOGICAL COMPOSITION OF BLOOD IN METASTATIC FORMS OF MAMMARY GLAND DISEASE IN DOMESTIC CATS
DOI:
https://doi.org/10.37000/abbsl.2025.115.08Keywords:
biochemical blood parameters, morphological blood parameters, mammary gland tumor, tumor metastases, domestic catAbstract
A study of biochemical and morphological changes in the blood composition in cats with malignant mammary tumors with metastases was conducted.
For the research conducted during the period 2022-24 at the Department of Surgery, Obstetrics and Small Animal Diseases of the Odessa State University and the Aibolit Veterinary Hospital, Odessa, 19 cats with malignant mammary tumors were selected. X-ray diagnostics of the chest cavity of cancer-infected animals was used to detect metastases in the lungs, which indicated metastatic forms of the lesion in cats. X-ray diagnostics of lung metastases in cats with oncopathology was performed in lateral projection using the X-ray diagnostic digital complex KRDC-02-Alpha.
In order to finally determine the nature of the tumors, histological studies of the surgical material were performed with fixation in 10% neutral formalin followed by staining with hematoxylin-eosin, of previously prepared paraffin sections, according to the author's method.
Biochemical parameters of blood of cats with cancer were analyzed on an automatic biochemical analyzer Chemray 240 using 15 standard parameters. Studies of the morphological composition of blood of cats with cancer were conducted on an HTI Micro CC-20 Plus hematological analyzer using 20 standard parameters.
It was diagnosed that 6 cats out of 19 had metastatic forms of mammary gland lesions; which amounted to 31.5% of the total number of animals studied, with the histological picture mainly revealing infiltrating lobular mammary gland carcinoma.
According to biochemical blood parameters, a significant increase in the serum levels of: urea, alkaline phosphatase, alpha amylase, aspartate transaminase (AST), alanine aminotransferase (ALT), and cholesterol was found in cats with metastatic mammary gland lesions.
In addition, a correlation was found between the metastatic form of mammary gland lesions in cats and morphological blood parameters: thrombocytopenia, increased ESR, lymphocytopenia, and segmental neutrophilia.
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