REGIONAL APPLICATION OF ANTIBIOTICS AND IODINE PREPARATIONS IN COMPLEX TREATMENT SCHEMES OF COWS WITH POST-BIRTH ENDOMETRITIS
Keywords:
uterus, endometritis, antibiotic, regional, intraarterial, paravaginal, iodine.Abstract
Post-calving endometritis in cows is one of the most common complications of the puerperium, can cause pathological changes not only in the uterus, but also in other parts of the reproductive system and in the body as a whole. The problem of acute purulent complications of the puerperium in cows becomes particularly acute when, against the background of a disorder of the body's defense mechanisms after childbirth, treatment is untimely and inadequate. The article presents the results of a study on the regional use of antibiotics, iodine preparations and amiridine preparations in complex treatment regimens for cows with post-calving endometritis. Comprehensive and sequential treatment regimens for patients with acute endometritis in cows have been scientifically substantiated, developed and tested. A characteristic feature of post-calving endometritis in cows is its wide variety of pathogens, mainly opportunistic microflora, which deprives this acute purulent disease of nosological specificity. Bacteriological studies identified bacterial microflora from uterine-vaginal secretions, determined antibiotic sensitivity of endometritis pathogens, according to which antimicrobial drugs were selected. As etiotropic therapy, based on the results of microbiological tests, combinations of antibiotics oxytetracycline and tylosin in combination with iodine preparations were selected. The basis of rational therapy of cows was regional administration of drugs: into the internal iliac artery, intravenously, paravaginally and intravaginally. It was established that combined intraarterial administration of antibiotics in combination with the uterotonic drug "amiridin" turned out to be a more effective method of treating cows with purulent endometritis than their intramuscular injections recommended by the guidelines. The introduction of antimicrobial drugs into the main vessel of the uterus allows to concentrate their pharmacological action in the pathological focus, which positively affected the results of treatment and restoration of the reproductive function of cows. This can be explained by the synergistic effect of this combination of antibiotics, supplemented with iodine therapy, as well as rational methods of their use.
References
Walsh, S., Williams, E., Evans, A. (2011) A Review of the Causes of Poor Fertility in High Milk Producing Dairy Cows. Animal Reproduction Science, 123, 127-138. DOI: 10.1016/j.anireprosci.2010.12.001. [in English].
Sheldon, I.M., Owens, S.E. (2017). Postpartum uterine infection and endometritis in dairy cattle. In Proceedings of the 33rd Annual Scientific Meeting of the European Embryo Transfer Association (AETE). Bath. UK. 8–9 September. 14, 622–629. DOI: http://dx.doi.org/10.21451/1984-3143-AR1006. [in English].
Herath, S., Dobson, H., Bryant, C. and Sheldon, I. (2006) Use of the Cow as a Large Animal Model of Uterine Infection and Immunity. Journal of Reproductive Immunology, 69, 13-22. https://doi.org/10.1016/j.jri.2005.09.007. [in English].
Bodnar, O. (2020). Analiz vzaiemozv’iazkiv pokaznykiv klitynnoho imunitetu orhanizmu koriv za pisliaotelnoho endometrytu [Analysis of the relationships between indicators of cellular immunity of the body of cows in post-hospital endometritis]. Podilskyi visnyk: silske hospodarstvo, tekhnika, ekonomika [Podilskyi Visnyk: Agriculture, Technology, Economics]. 32, 166-171. DOI:
https://doi.org/10.37406/2706-9052-2020-2-18. [in Ukrainian].
Sheldon, I.M., Cronin, J., Goetze, L., Donofrio, G., Schuberth, H.J. (2009) Defining Postpartum Uterine Disease and the Mechanisms of Infection and Immunity in the Female Reproductive Tract in Cattle. Biology of Reproduction, 81, 1025-1032. https://doi.org/10.1095/biolreprod.109.077370. [in English].
McDougall, S., Hussein, H., Aberdein, D., Buckle, K., Roche, J., Burke, C., et al. (2011) Relationships between Cytology, Bacteriology and Vaginal Discharge Scores and Reproductive Performance in Dairy Cattle. Theriogenology, 76, 229-240.https://doi.org/10.1016/j.theriogenology.2010.12.024. [in English].
Masera, J., Gustafsson, B.K., Afiefy, M.M., Stowe, C.M., Bergt, G.P. (1980). Disposition of oxytetracycline in the bovine genital tract: systemic vs intrauterine administration. J. of the Am. Vet. Med. Assoc. 176, 1099-1102. [in English].
Jeremejeva, J., Orro, T., Waldmann, A., Kask, K. (2012). Treatment of dairy cows with PGF2α or NSAID, in combination with antibiotics, in cases of postpartum uterine inflammation. Acta. Vet. Scand. 54, 45. DOI: https://https://doi.org/10.1186/1751-0147-54-45. [in English].
Smith, B.I., Donovan, A., Risco, C., Littell, R., Young, C., Stanker, L.H., Elliott, J. (1998). Comparison of various antibiotic treatments for cows diagnosed with toxic puerperal metritis. J. Dairy Sci. 81, 1555-1562. DOI: https://10.3168/jds.S0022-0302(98)75721-2. [in English].
Kernychnyi, S.P. Patohenetychne obgruntuvannia likuvannia koriv, khvorykh na khronichnyi hniino - kataralnyi endometryt: Avtoref. dys kand. vet. Nauk. [Pathogenetic foundations of treatment of diseases of the gastrointestinal tract, chronic purulent-catarrhal endometrium: Author's note. Diss. kand. vet. nauk: 16.00.07]. Kyiv. 19 p. [in Ukrainian].
Deori, S., Phookan, A. (2015). Bovine Postpartum Metritis and its Therapeutics: A Review. Indian Journal of Science and Technology. 8 (23), 1-5. DOI: 10.17485/ijst/2015/v8i23/52386. [in English].
Haimerl P., Heuwieser W. Invited review: Antibiotic treatment of metritis in dairy cows: a systematic approach. J. Dairy Sci. 2014. Vol. 97. Р. 6649–6661. DOI: https://doi.org/10.3168/jds.2014-8462. . [in English].
Várhidi, Z., Csikó, G., Bajcsy, Á.C., Jurkovich, V. (2024). Uterine Disease in Dairy Cows: A Comprehensive Review Highlighting New Research Areas. Journals Veterinary Sciences.11(2). DOI: https://doi: 10.3390/vetsci11020066. [in English].
Bodnar, O. (2021). Efektyvnist terapii koriv za pisliaotelnoho hniinoho endometrytu zalezhno vid sposobu vvedennia preparativ [The effectiveness of treatment of cows with post-calving purulent endometritis depending on the method of drug administration]. Ahrarnyi visnyk Prychornomor’ia. [Аgrarian Bulletin of the Black Sea Littoral].101, 40-43. DOI:10.37000/abbsl.2021.101.07 [in Ukrainian].
Bodnar, P.M., Mykhalchyshyn, G.P., Komisarenko, Yu.I. and others (Eds.). (2013). Endocrinology: Textbook for students of the National Medical University of Ukraine. Vinnytsia: Nova Kniga. [in Ukrainian].
Bodnar, O.O., Kernychnyi, S.P., Zakharova, T.V., Bodnar, O.O. (2016). Regionarne zastosuvannia antybiotykiv ta preparativ yodu v kompleksnykh skhemakh likuvannia koriv za hniinoho endometrytu [Regional use of antibiotics and iodine preparations in complex treatment regimens for cows with purulent endometritis]. Nauk.visnyk NUBiP Ukrainy [Sci. Bulletin of the NUBiP of Ukraine]. 237, 149-158. [in Ukrainian].
Sposib yodoterapii koriv za endometrytu: pat. 70074 Ukraina. № 13536; zaiavl. 17.11.2011; opubl. 25.05.2012; Biul. №10. 3 s. [Method of iodine therapy of cows for endometritis: pat. 70074 Ukraine]. No.13536; appl. 11.17.2011; publ. 05.25.2012; Bull. No.10. 3 p. [in Ukrainian].
Sposib likuvannia hniinoho endometrytu u koriv: pat. 85115 Ukraina. № 03110; zaiavl. 23.03.2007; opubl. 25.12.2008, Biul. № 24. 3 s. [Method of treating purulent endometritis in cows: pat. 85115 Ukraine]. No. 03110; appl. 23.03.2007; publ. 25.12.2008, Bull. No. 24. 3 p. [in Ukrainian].
Sposib likuvannia vestybulovahinitu u koriv: pat. 85118 Ukraina; № 200703665; zaiavl. 03.04.2007; opubl. 25.12.2008; Biul. №24. 4 s. [Method of treating vestibulovaginitis in cows: Pat. 85118 Ukraine]. No. 200703665; appl. 03.04.2007; publ. 25.12.2008; Bull. No. 24. 4 p. [in Ukrainian].
Parmar, K.H. (2021). Endometritis in Bovine: A Review. Agricultural Reviews. 42(3), 342-347. DOI:10.18805/ag.R-2038. [in English].
Judith, A.M. Wessels, M.R. Wessels, D.F., Twomey, J.R. (2014). Adverse Reaction to Presumed Intra-arterial Ceftiofur Suspension Injection in Dairy Cattle. Journal of Comparative Pathology. 150(1):91. DOI:10.1016/j.jcpa.2013.11.067. [in English].
Bodnar, O.O., Kernychnyi, S.P., Biletskyi, V.S., Mizyk, V.P. (2013). Regionarna yodoterapiia za endometrytu u koriv. [Regional iodine therapy for endometritis in cows.]. Visnyk Sumskoho Natsionalnoho ahrarnoho universytetu. Seriia “Veterynarna medytsyna” [Bulletin of the Sumy National Agrarian University. Series “Veterinary Medicine”]. 1(30).135-137. [in Ukrainian].
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