PATHOGENETIC ASPECTS AND PATHOMORPHOLOGICAL CHANGES IN UROGENIC PYELONEPHRITIS

Abstract

According to the results of the post-mortem examination of the corpse of the domestic dog, the following were diagnosed: dermatitis; balanoposthitis, prostatitis; urethritis, cystitis, pyelonephritis, nephritis; alterative myocarditis, endocarditis; venous hyperemia of the lungs; chronic alternative hepatitis; pancreatitis; atrophy of the spleen; chronic lymphanodulitis (exacerbation period); hemorrhagic diathesis of serous membranes (trachea, epicardium, bladder, liver), lymph nodes, thymus; amputated stump of the pelvic limbs in the area of the distal and middle phalanx of the fingers, hyperkeratosis; catarrhal enteritis, intestinal flatulence, worm infestation. Significant pathomorphological changes in the urogenital tract, which included pyelonephritis, balanoposthitis, epididymitis, urocystitis, urethritis, make it possible to assume that the genitourinary system was the primary focus of the infectious process. Further spread of the infectious agent by hematogenous route led to secondary lesions of various internal organs. Chronic urogenic (ascending) pyelonephritis led to the development of chronosepsis. Multiple organ failure led to intoxication of the body with the development of blood hemolysis. A detailed analysis of pathomorphological changes and pathogenetic mechanisms of disease-causing processes that led to them is the main purpose of this work.