HEMOSTASIS OF COWS IN THE FIRST THREE MONTHS OF PREGNANCY

Authors

  • D. Matviichuk Sumy National Agrarian University

DOI:

https://doi.org/10.37000/abbsl.2023.106.06

Keywords:

cow, weight, hemostasis, trimester, first

Abstract

Obtaining healthy young animals and high productivity from cows depends on the physiological and biochemical status of the animal organism. A significant role in this process belongs to the system of hemostasis, the formation of the feto-placental complex, the maximum supply of nutrients and oxygen to the fetus. Platelet hemostasis of cows undergoes significant changes during pregnancy. They testify that during the period of bearing the fetus, the state of vascular and platelet hemostasis of the animal acquires the corresponding regularities in the dynamics. It was established that the period of fetal nidation is accompanied by a decrease in the number of blood platelets in the blood of cows by 1.16 times, compared to the indicator of non-calving animals (p < 0.05. in the blood was found to be 1.17 – 1.16 times (p < 0.05) less than in control cows. The number of platelets in the blood of cows from the first trimester of pregnancy to the end of the third trimester decreases by 1.17 (p < 0 .05), 1.28 (p<0.05) and 1.33 times (p<0.01), and 1.27 times (p<0.01) during the entire calving period. In calving cows at the end in the first trimester of pregnancy, the prothrombin time was 1.21 times (p<0.05), shorter, compared to this indicator of cows of the control group. In pregnant cows, the prothrombin time of hemostasis decreased from the first trimester of pregnancy. On average, over the entire period of pregnancy in cows, the prothrombin time was 1.34 times less than in non-calving cows (p<0.01). it is also shown by the prothrombin index of hemostasis of cows. In cows, the prothrombin index consistently decreased during the first trimester (p<0.05). We found significant changes in the content of fibrinogen in the blood of cows. In pregnant animals, the content of fibrinogen in the blood gradually increased and at the end of the first trimester of pregnancy was more than at the beginning of pregnancy. Changes in the dynamics of indicators of prothrombin and thrombin time of hemostasis, the content of fibrinogen in the blood of cows during this gestation period affect the properties of blood. By the end of the first trimester of pregnancy, the viscosity of the cows' blood increased, and the coagulation rate of the blood of pregnant cows increased.

References

Cohen, С.Т., Turner, N.A. & Moake, J.L. (2020). Рroduction and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts. Sci Rep,1 (10), 4

M. D. Kambur, A. A. Zamaziy, A. V. Kolechko, A. Y. Lermantov, O. V. Butov. The quality of the blood of cows during pregnancy and their effects on reproduction and survival of newborn calves / Science and Education a New Dimension volume VI (157) issue 17 Р.26 – 29 https://doi.org/10.31174/send-nt2018-157vi17-06

Zamaziy A. Dynamics of platelet hemostasis of pregnant cows // Scientific Horizons. Vol 71, issue 9-10, P 23 – 29 https://doi.org/10.33249/2663-2144-2018-71-9-10-23-29

Physiology of animals (2008.) // [Mazurkevych A. Y., Karpovskyy v. I., Kambur M. D., Zamyziy A. A. etc.] ; by Ed. Mazurkiewicz and V. I. Karpovsky. Tutorial. VINNITCA: New book, 424.

Kambur М. D., Zamaziy A. A., Koleschko A V., Lermontov A. Yu., Butov O. V. (2018). Properties of blood cows during the period of their being, their influence on reproductive function of animals and viability of newborn calves. Budapest, Vengryya. Science and Education a New Dimension. Natural and Technical Sciences, VI (17), Issue: 157, Р. 26-29.

Hoffman M, Monroe DM. Coagulation (2007): A modern view of hemostasis. Hemato Oncol Clin North Am., 21(1),1-11. https://doi.org/10.1016/j.hoc.2006.11.004

Markin L. B., Palyga I. E. Technology of help in chronic prenatal hypoxia/L. B. Markin, I. E. Palyha (2004) //Practical medicine, 3,24 – 27. DOI: 10.1161/Circresaha.110.221259

Vink J.Y. (2006). Amniotic fluidin dexand birth weight: istherearelalation shipin diabetics with poorglucemic control / J.Y. Vink, S.H. Poggi // Am. J. Obstet. Gynecol, 195 (3), 848 –850. doi: 10.1016/s0002-9378(00)70343-7.

Veterinary obstetrics, gynecologists and biotechnology of reproduction of animals with the basics of andrology/ (2006)/ V. A. Yabloskyi, S. P. Khomych, G. M. Kalinowski, G. Haruta, M. I. Kharenko, v. I. Zavijuha, V. Lyubetskoy. Tutorial. Vinnitca.: Newbook, 592 pp.

Vereina N.K., Sinitsyn S.P., Chulkov V.S. Dynamics of hemostasis indicators in physiologically occurring pregnancy. Clinical laboratory diagnostics, 2012 – 243 р.

Falati S, Gross Р. Merrill-Skoloff G. Real time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med. 2002; 8(10), P. 187–198. https://doi.org/10.1385/1-59259-782-3:187

Blomback В. Fibrinogen and fibrin - proteins with complex roles in hemostasis and thrombosis. Thromb Res. 1996: 83(1):1–75. https://doi.org/10.1016/0049-3848(96)00111-9.

Hillary A. Physiological implications of adenosine receptor-mediated platelet aggregation Cell. Physiol. 2010, 226: 46–51. https://doi.org/10.1002/jcp.22379

Klevets M.Iu. Fiziolohiia liudyny i tvaryn (fiziolohiia nervovoi, miazovoi i sensornykh system) / M. Yu. Klevets, V. V. Manko, M. O. Halkiv, ta in. – Lviv : LNU imeni Ivana Franka, 2011. 304 s.

Prosianyi S. Khimichnyi sklad krovi materiv ta yikhnikh plodiv chorno-riaboi khudoby riznykh henotypiv / S. Prosianyi, Y. Siratskyi, O. Danylkiv // Tvarynnytstvo Ukrainy. – №8. – 2005. – S. 19–20.

Longstaff, C.& Kolev, K. (2015). Basic mechanismsand regulation of fibrinolysis. J ThrombHaemost,98 (13), 105.

Ratajczak, M.Z. & Ratajczak, J. (2020). Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future? Leukemia. 34(12), 3126-3135.

Xinge, Yu, Zihui, Wang, Yang & Li, V. (2022) Metal ion chelation enhances tissue plasminogen activator (tpa)-induced thrombolysis: an in vitro and in vivo study. J Thromb Thrombolysis., 2 (53), 291-301.

Whyte, C., Mitchell, J. &Mutch, N. (2017). Platelet-Mediated Modulation of Fibrinolysis. SeminThrombHemost., 2 (43), 115-128.

Whyte, C.,Mitchell, J. &Mutch, N. (2017). Platelet-mediated modulation of fibrinolysis. SeminThromb Hemost, 2 (43), 115-128.

Published

2023-05-09

How to Cite

Матвійчук, Д. (2023). HEMOSTASIS OF COWS IN THE FIRST THREE MONTHS OF PREGNANCY. Agrarian Bulletin of the Black Sea Littoral, (106). https://doi.org/10.37000/abbsl.2023.106.06