DYNAMICS OF SEX STEROID HORMONES, CORTISOL AND TRIIODOTHYRONINE IN DOGS DURING THE ESTROUS CYCLE

Authors

  • V. Kyrychenko Odesa State Agrarian University
  • M. Broshkov Odesa State Agrarian University

DOI:

https://doi.org/10.37000/abbsl.2022.104.03

Keywords:

progesterone, estradiol, cortisol, triiodothyronine, estrus, female dogs

Abstract

The article presents the resulting data of study the relationship of estradiol, progesterone, cortisol and triiodothyronine in blood serum in the dynamics of their content during the estrous cycle in female dogs. Blood serum was used for the study, blood was collected from the lateral subcutaneous vein of the forearm on 1, 5, 10, 15, 20, 25 days of the estrous cycle. The analysis of the concentration of progesterone in the blood serum of bitches had regular changes during estrus. An increase in the concentration of cortisol in the blood serum during the first 10 days of estrus indicates that the changes occurring in the body during the cycle are stressful. The obtained data on the dynamics of estradiol during estrus correspond to other studies. Specifically, they indicate that during estrus, the estrogen content drops, and the progesterone level begins to rise.

References

Freshman Joni L. (2001). Clinical Management of the Subfertile Stud Dog. Veterinary Clinics of North America: Small Animal Practice, 31 (2). 259-269. https://doi.org/10.1016/S0195-5616(01)50204-1.

Cho, S. J., Ning, M., Zhang, Y., Rubin, L. H., & Jeong, H. (2016). 17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α. Acta pharmaceutica Sinica. B, 6(5), 504–509. https://doi.org/10.1016/j.apsb.2016.04.005

Collier, A. C., Ganley, N. A., Tingle, M. D., Blumenstein, M., Marvin, K. W., Paxton, J. W., Mitchell, M. D., & Keelan, J. A. (2002). UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term. Biochemical pharmacology, 63(3), 409–419. https://doi.org/10.1016/s0006-2952(01)00890-5

Zoldag, L., Kecskemethyl, S., & Nagy, P. (1993). Heat progesterone profiles of bitches with ovulation failure. Journal of Reproduction and Fertility, 47, 562–563.

Wingfield, J.C., & Romero, L.M. (2011). Adrenocortical Responses to Stress and Their Modulation in Free‐Living Vertebrates. Comprehensive Physiology, 211-234.

Cohen, A. A., Martin, L. B., Wingfield, J. C., McWilliams, S. R., & Dunne, J. A. (2012). Physiological regulatory networks: ecological roles and evolutionary constraints. Trends in ecology & evolution, 27(8), 428–435. https://doi.org/10.1016/j.tree.2012.04.008

Hau, M., Ricklefs, R. E., Wikelski, M., Lee, K. A., & Brawn, J. D. (2010). Corticosterone, testosterone and life-history strategies of birds. Proceedings. Biological sciences, 277(1697), 3203–3212. https://doi.org/10.1098/rspb.2010.0673

Romero L. M. (2004). Physiological stress in ecology: lessons from biomedical research. Trends in ecology & evolution, 19(5), 249–255. https://doi.org/10.1016/j.tree.2004.03.008

Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000). How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine reviews, 21(1), 55–89. https://doi.org/10.1210/edrv.21.1.0389

Nakao, N., Ono, H., & Yoshimura, T. (2008). Thyroid hormones and seasonal reproductive neuroendocrine interactions. Reproduction (Cambridge, England), 136(1), 1–8. https://doi.org/10.1530/REP-08-0041

Lovick, T. A., & Zangrossi, H., Jr (2021). Effect of Estrous Cycle on Behavior of Females in Rodent Tests of Anxiety. Frontiers in psychiatry, 12, 711065. https://doi.org/10.3389/fpsyt.2021.711065

Thuróczy, J., Müller, L., Kollár, E., & Balogh, L. (2016). Thyroxin and progesterone concentrations in pregnant, nonpregnant bitches, and bitches during abortion. Theriogenology, 85(6), 1186–1191. https://doi.org/10.1016/j.theriogenology.2015.11.035

Marinelli, L., Rota, A., Carnier, P., Da Dalt, L., & Gabai, G. (2009). Factors affecting progesterone production in corpora lutea from pregnant and diestrous bitches. Animal reproduction science, 114(1-3), 289–300. https://doi.org/10.1016/j.anireprosci.2008.10.001

Groppetti, D., Aralla, M., Bronzo, V., Bosi, G., Pecile, A., & Arrighi, S. (2015). Periovulatory time in the bitch: what's new to know?: Comparison between ovarian histology and clinical features. Animal reproduction science, 152, 108–116. https://doi.org/10.1016/j.anireprosci.2014.11.008

Steckler, D., Nöthling, J. O., & Harper, C. (2013). Prediction of the optimal time for insemination using frozen-thawed semen in a multi-sire insemination trial in bitches. Animal reproduction science, 142(3-4), 191–197. https://doi.org/10.1016/j.anireprosci.2013.09.013

Thomassen, R., Sanson, G., Krogenaes, A., Fougner, J. A., Berg, K. A., & Farstad, W. (2006). Artificial insemination with frozen semen in dogs: a retrospective study of 10 years using a non-surgical approach. Theriogenology, 66(6-7), 1645–1650. https://doi.org/10.1016/j.theriogenology.2006.01.022

de Gier, J., Kooistra, H. S., Djajadiningrat-Laanen, S. C., Dieleman, S. J., & Okkens, A. C. (2006). Temporal relations between plasma concentrations of luteinizing hormone, follicle-stimulating hormone, estradiol-17beta, progesterone, prolactin, and alpha-melanocyte-stimulating hormone during the follicular, ovulatory, and early luteal phase in the bitch. Theriogenology, 65(7), 1346–1359. https://doi.org/10.1016/j.theriogenology.2005.08.010

Concannon PW, Hansel W, McEnteе K. (1977). Changes in LH, progesterone and sexual behavior associated with preovulatory luteinization in the bitch. Biol. Reprod. 17: 604-613.

Bordjugov KS, Bordjugova SS, Kot VS. (2013). Rizni metody vyznachennja ovuljacii' u sobak [Different methods for determining ovulation in dogs]. Visnyk Poltavs'koi' Derzhavnoi' Agrarnoi' Akademii' 1: 116-119 (in Ukrainian).

Haase, C. G., Long, A. K., & Gillooly, J. F. (2016). Energetics of stress: linking plasma cortisol levels to metabolic rate in mammals. Biology letters, 12(1), 20150867. https://doi.org/10.1098/rsbl.2015.0867

Reimers, T & Mummery, L & Mccann, Joseph & Cowan, R & Concannon, Patrick. (1984). Effects of reproductive state on concentrations of thyroxine, 3,5,3'-triiodothyronine and cortisol in serum of dogs. Biology of reproduction, 31. 148-54.

Published

2022-11-08

How to Cite

Кириченко, В., & Брошков, М. (2022). DYNAMICS OF SEX STEROID HORMONES, CORTISOL AND TRIIODOTHYRONINE IN DOGS DURING THE ESTROUS CYCLE. Agrarian Bulletin of the Black Sea Littoral, (104). https://doi.org/10.37000/abbsl.2022.104.03