HEMATOLOGICAL CHANGES AND THE EFFECTIVENESS OF THERAPY ACCORDING TO GENERALIZED FORM OF DOGS' DEMODICOSIS
DOI:
https://doi.org/10.37000/abbsl.2021.99.16Keywords:
dogs, blood, drug, wax moth, mitesAbstract
The study of demodecosis invasion intensity in dogs under a generalized form of demodecosis has established that on the 10th day of treatment this index decreased from 17.9 ± 0.79 tо 5.9 ± 0,20 tick specimen in a smear, and on the 20th day no active disease agent was registered.The result was similar for animals which received Dectomax + Sulphurous-tar leniment + Tylosin, and for those which were treated according to the schedule: Dectomax + 2.5% Waxworm extraction + Sulphurous-tar leniment + Waxworm + 5% Tylosin . Dectomax showed 100% effectiveness as to demodecosis agents, but disease management therapy did not have any impact on its acaricide effect as to demodecosis. After a daily clinical examination of dogs of the first experimental group it has been found that the itches dissappeared on the 5th day of treatment, the appetite appeared on the 10th day, fistula and nodules skinned over on the 16th day, the affected skin got softer and thinner on th 21st day, canine hair on the affected skin ares started growing on the 24th day. The animals of the second experimental group additionally received preparations containing Waxworm, thus analogical results were achieved on the 3rd, 5th, 10th, 15th and 18th day of treatment respectively.
The morphological examination of animals blood on the 30th day of treatment showed that after treating animals of the second experimental group with a complex of preaparations, the amount of leucocytes in blood decreased from 11.40 ± 0.35 tо 8.90 ± 0.31 g/l ( by 21.9%), eosinophiles amount decreased from 3.9 ± 0.15 tо 3.40 ± 0.10 % ( by 12,8), the amount of banded neutrophiles decreased from 5.70 ± 0.20 tо 4.80 ± 0.77% (by 15.8) as compared to the indices of the dogs which received only Dectomax + Sulphurous-tar leniment + 5% Tylosin (p<0.05).
The indices of hemoglobulin, albumen, total bilirubin as well as of AlAT and AcAt activity on the 10th, 20th and 30th day of treatment confirm the normalization of hepocytes functioning.
References
Wol R. ( 2006 ). Taxonomic priority in Psoroptes mange mites: p.ovis or p.egui. Exp. Appl. Acarol.-V.39-№2.-p.159-162.
Bengnet Г.(2015). Comparative efficocy of two oral treatments for dogs containing either afoxalaner or fluralaner against Ripicephalus sanguineous sepsu lato and Dermacentor reticulates.
Parasitology.-№ 209- p.112-145.
Євстафєва В.О. (2015) Поширення акарозів собак в умовах міста Кременчуга . Вісн.Полтав. держ. аграр.акад.-№ ½.-с.91-94.
Brimer l. (2004) Rapid guantitatiue assay for acaridae effects on Sarcoptes scabiei voor. snis and Otodectes cynotis.Exp.Appl.
Acarol-V .33.-№2.-p.81-91.
Nutting W.B. (1976). Hair follicle mites ( Demodex xp.) of medical and veterinary concern. Cornell Vet – V.66.-№1.-p.-21-25.
Hasegawa T.A. (1995) .A cose report of the management of democosin the golden hamster. Vet.- Med.Sci.-V.57.-№2-p.337-338.
Фирсов Н.Ф.(2000).Эпизотология и терапия демодекоза собак по урбанизированих териториях юга Росии.Весн.ветеринарии.-№ 21/4/.-с.27-38.
Ravera I.(2013). Small Demodex populations colonize most parts of the skin of healthy dogs. Vet.Dermology.№24.-p.168-170.
Gaafar S.M.(1959). Apporently incidence of Demodex sp. in skins of apparently normal dogs.-№133.-p.122-123.
Головко А.Н.(1997). Заболеваемость демодекозом собак разных пород. Зб.мат. II міжнар.наук.-практ.конф.”Проблеми ветеринарного обслуговування дрібних домашніх тварин “.К.-№3.-с.27-35.
Ларионов С.В.(1991) . Видовые морфологические различия клещей демодексов. Токсикология и защита сельскохозяйственных животных от эктопаразитов .М.,-с.20-30.
Слесарева Д.А.(2007). Энтеросорбция в комплексной терапии больных демодекозом.Тр.V Науч.- практ. конф. «Актуальные вопросы патологии кожи и урогенитальных инфекцый». – Одесса – с.90-91.
Letendre L.(2014). The intravenous and oral pharmacokinetics afoxolaner, a novel isoxazoline, used as a monthly clewable antiparasitic for dogs. Vet.Parasitology.-№201.-p.190-`197.
Mueller R.S.(2004).Treatment protocols for demodicosis: an evidence baset review.Vet.Dermatology.-V.15.-p.75-89.
Слесарева Д.А.(2007) Комплексные подходы к лечению демодекоза в практике дерматокосметолога . Мат. наук.- практ. конф. « Сучасний менеджмент в дерматовенерології : діягностичні, лікувальні та організаційно- прарові аспекти» .- Київ.-с.93-94.
Опанасюк А.С.(2000). Применения дектомакса при демодекозе собак. Пробл. стабилизации и развития сел. хоз-ва Казахстана, Сибири и Монголии.- Новосибирск.-с.190.
Корпищенко А.И.(1997). Медицинская лабораторная диагностика .Санкт- Петербург: интермедика – 297 с.
