DIAGNOSIS AND TREATMENT OF BABESIOSIS IN DOGS, FEATURES OF THE USE OF UKRAINIAN THERAPEUTIC DRUGS
DOI:
https://doi.org/10.37000/abbsl.2020.97.03Keywords:
babesiosis of dogs, treatment, Azidine-vet, Imkar-120Abstract
Babesiosis is registered throughout Europe. The outcome of treatment depends on early diagnosis and rapid use of effective drugs. A large number of chemical compounds have been reported to be effective against babesia in dogs. Some of them are highly specific and highly effective, but many of them have their own application features. The research was conducted in Khmelnytsky region during 2018-2019. Spontaneously affected dogs (n = 38), with a laboratory-confirmed diagnosis of babesiosis (Babesia canis) were divided into two experimental groups, 19 dogs in each. In the first experimental group for the treatment of babesiosis used the drug Azidine-vet at a dose of 3.5 mg / kg, in the second - Imkar-120 at a dose of 5 mg / kg.
The diagnosis babesiosis was established comprehensively using epidemiological data, clinical signs and laboratory tests. When using Azidine-vet on the 5th day, a slight decrease in hematocrit was observed, while Imkar-120 caused an increase in this level from the 5th day. In the group where Azidin-vet was used for 7 days, the level of erythrocytes remained below normal, while in the other group, where Imkar-120 was used, on the 5th day these indicators increased slightly. When using Imkar-120 creatinine level stabilized on the 6th day, while with the use of Azidine-vet serum creatinine returned to normal only on the 9th day. After treatment of Imkar-120 we observed a sharp decrease in urea for 5 days of treatment. In animals treated with Azidine-vet, stabilization of urea levels occurred only on the 9th day of treatment. In animals treated with Imkar-120, normalization of AST was observed on the 7th day of treatment, ALT - on the 10th day. With the use of Azidine-vet the level of AST was stabilized for 10 days, and ALT - only for 14 days. Accordingly, the therapeutic effect of Imkar-120 was higher compared to Azidine-vet.
The therapeutic efficacy of Imkar-120 and Azidine-vet for the treatment of canine babesiosis was 100%. However, during treatment, each of the drugs corresponded to its own dynamics of impact on the organism of sick dogs.
References
2. Homer M.J., Aguilar-Delfin I., Telford S.R., Krause P.J., Persing D.H. Babesiosis. Clin Microbiol Rev. 2000; 13(3):451–69. https://doi.org/10.1128/cmr.13.3.451-469.2000 PMID: 10885987
3. Control of Vector-Borne Diseases in Dogs and Cats. ESCCAP Guideline 05 Third Edition – March 2019.
4. Левицька В. А., Мушинський А.Б., Березовский А. В.. Видовий склад іксодових кліщів у Західному регіоні України. Науковий вісник ЛНУВМБ імені С.З. Ґжицького. 2020. Т. 22, № 97. С. 187–193. https://doi.org/10.32718/nvlvet9730
5. Didyk Y.M., Blaňárová L., Pogrebnyak S., et al. Emergence of tick-borne pathogens (Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, Ricketsia raoultii and Babesia microti) in the Kyiv urban parks, Ukraine. Ticks and Tick-borne Diseases. 2017 Feb;8(2):219-225. DOI: 10.1016/j.ttbdis.2016.10.002.
6. Irwin P.J. Canine babesiosis: from molecular taxonomy to control. Parasit Vectors. 2009;2(Suppl. 1):S4.
7. Baneth G., Cardoso L., Brilhante‐Simões P., Schnittger L.. Establishment of Babesia vulpes n. sp. (Apicomplexa: Babesiidae), a piroplasmid species pathogenic for domestic dogs. Parasit Vectors. 2019;12:129.
8. Solano‐Gallego L., Baneth G. Babesiosis in dogs and cats—expanding parasitological and clinical spectra. Vet Parasitol. 2011;181:48–60.
9. Baneth G. Antiprotozoal treatment of canine babesiosis. Vet Parasitol. 2018;254:58-63. doi:10.1016/j.vetpar.2018.03.001
10. Young K.M., Corrin T., Wilhelm B., Uhland C., Greig J., Mascarenhas M., et al. Zoonotic Babesia: A scoping review of the global evidence. PLoS ONE 14(12): e0226781. 2019. https://doi.org/ 10.1371/journal.pone.0226781
11. Vial H.J.; Gorenflot A., Chemotherapy against babesiosis. Veterinary parasitology, 2006, 138, (1-2), 147-160.
12. Kuttler K.L. In Babesiosis. Ristic, M.; Keire, J.P., Eds.; Academic Press: New York, 1981, p 25-63.
13. Bajer A., Mierzejewska E.J., Rodo A., Welc-Falęciak R. The risk of vector-borne infections in sled dogs associated with existing and new endemic areas in Poland. Part 2: Occurrence and control of babesiosis in a sled dog kennel during a 13-year-long period. Vet. Parasitol. 202, 2014. 234–240.
14. Eichenberger R.M., Riond B., Willi B., Hofmann-Lehmann R., Deplazes P., Prognostic markers in acute Babesia canis infections. J. Vet. Intern. Med. 30, 2016. 174–182.
15. Beugnet F., Moreau Y. Babesiosis. Rev. Sci. Tech. 34, 2015. 627–639.
16. AbouLaila M., Sivakumar T., Yokoyama N., Igarashi I. Inhibitory effect of terpene nerolidol on the growth of Babesia parasites. Parasitology international, 2010, 59, (2), 278-282.
17. Mosqueda J., Olvera-Ramirez A., Aguilar-Tipacamu G., Canto G.J. Current advances in detection and treatment of babesiosis. Curr Med Chem. 2012;19(10):1504-1518. doi:10.2174/092986712799828355
18. Zygner W., Gójska-Zygner O., Norbury L.J., Wedrychowicz H. Increased AST/ALT ratio in azotaemic dogs infected with Babesia canis. Pol J Vet Sci. 2012;15(3):483-486. doi:10.2478/v10181-012-0074-7
19. M ́ath ́e A., Vo ̈ro ̈s K., Papp L., Reiczigel J. Clinical manifestations of canine babesiosis in Hungary (63 cases). Acta Vet Hung 54: 367-385. 2006.
20. De Scally M.P., Lobetti R.G., Reyers F., Humphris D. Are urea and creatinine values reliable indicators of azotaemia in canine babesiosis? J S Afr Vet Assoc 75: 121-124. 2004.
21. Беломытцева Е.С., Сафиуллин Р.Т. Эффективность применения препарата Дипрокарб при бабезиозе плотоядных в Москве и Московском регионе. Российский паразитологический журнал. М., 2017. Т.40. Вып.2.
22. Акимов Д. Ю., Романова Е. М., Шадыева Л. А. Сравнительная оценка эффективности препаратов на основе имидокарба и диминазина при бабезиозе. Вестник Ульяновской государственной сельскохозяйственной академии, (3 (35)), 49-54. 2016.
